The Raine Study
The Western Australian Pregnancy Cohort (Raine) Study is the world’s first pregnancy-intensive cohort study and is one of the largest medical research studies in Australia. WIRF hosted the early beginnings of this project and continues to be a major contributor. The Study commenced in 1989 with the recruitment of 2900 women who were less than 18 weeks pregnant at King Edward Memorial Hospital.
Initially, the focus of this study was to examine the effects of repeated ultrasound imaging and placental blood flow studies during pregnancy; however, the long term value of this unique cohort was also recognised, and the study continued into childhood, adolescence and now adulthood. Over the past 27 years, the 2868 children born into the Raine Study, and their parents, have generously participated in 11 cohort reviews at ages 1, 3, 5, 8, 10, 14, 17, 18, 20, 23 and now 27. The Raine Study now encompasses many special interest study groups, includes more than 150 Australian and international researchers, and contributes to numerous multinational research consortia.
This year, the Raine study has continued to generate new insights into the genetic and environmental antecedents of complex human diseases, including coronary heart disease, stroke, insulin resistance, type-two diabetes and high cholesterol levels, obesity, neurological disorders and mental illness. The Raine Study is currently conducting the 27 year cohort review. This review is focused on cardiovascular health and the distribution of fat inside the body.
Over the Study’s 28 year history, more than 300 peer-reviewed journal articles have been published. More than 15 of these articles have been published in prestigious journals such as Nature, Nature Genetics and the Lancet. The Study’s rich resources include thousands of measurements on each participant, and millions of genetic data-points. The generosity of the Raine Study participants and families will enable the study team to continue to contribute to the global research community and support health development for many years into the future.
The Original Raine Study Research Team outside Carson House, 1989