Haruo Usuda

Haruo Usuda is a Clinical Senior Lecturer of Obstetrics and Gynaecology at The University of Western Australia. He is also Head of the WIRF Perinatal Research Laboratories and Head of Artificial Placenta Project.

He received his medical degree from the Tohoku University, Japan. His clinical interests are Obstetrics, Gynaecology, Neonatology, Perinatology, Paediatrics, Neonatal Resuscitation, and Fetal Medicine.

EVE Therapy: A New Life Support System for Preterm Babies Born at the Border of Viability
Kemp, M., Newnham, J. & Usuda, H.
National Health & Medical Research Council NHMRC
1/01/19 → 31/12/21　(Project: Research)

Preclinical evaluation of a novel allosteric IL-1R inhibitor (rytvela) for the prevention of perinatal inflammation-induced fetal injury
Keelan, J., Olson, D., Robertson, S., Kemp, M., Ellery, S. & Usuda, H.
National Health & Medical Research Council NHMRC
1/01/18 → 31/12/22 (Project: Research)

Preterm lung and brain responses to mechanical ventilation and corticosteroids
Kemp, M. & Usuda, H.
National Institute on Aging
5/04/22 → 31/12/23 (Project: Research)

• 2021    M.D. PhD Tohoku University School of Medicine, Sendai, Miyagi, Japan
• 2007     M.D. Tohoku University School of Medicine, Sendai, Miyagi, Japan
• 2001     Graduated from Gunma Prefecture Maebashi High School, Gunma, Japan

SRI President’s Presenter’s Award
70th Society for Reproductive Investigation. (Brisbane, Australia. Mar22-25, 2023) 
Title: Maintenance of Extremely Preterm Ovine Fetuses for Two Weeks Using an Artificial Placenta.

JSOG Congress Award: 
75th Annual Congress of the Japan Society of Obsterics and Gynecolgy　(Tokyo. Japan, May 13-15, 2023)
Title：Maintenance of Extremely Preterm Ovine Fetuses for Two Weeks Using an Artificial Placenta.

Laxmi Baxi Award:
69th Society for Reproductive Investigation. (Denver, USA. Mar15-19, 2022) 
Title: Low-dose antenatal betamethasone treatment achieves preterm lung maturation 
equivalent to the WHO dexamethasone regimen but with reduced HPA axis disruption in a sheep model of pregnancy

Early Career Investigator Awards:
67th Society for Reproductive Investigation. (Vancouver, Canada. Mar12-15, 2020) 
Title: First Use of an Artificial Placenta to Support Extremely Preterm Sheep Fetuses Compromised by Intrauterine Inflammation. 

JSOG Congress Award: 
71th Annual Congress of the Japan Society of Obsterics and Gynecolgy　(Nagoya. Japan, Apr 11-14, 2019)
Title：First achievement of successful maintenance in 95 days extremely preterm lambs.treated with Ex Vivo Uterine Environment（EVE）Therapy

2023
Yusaku Kumagai, Matthew W Kemp, Haruo Usuda, Tsukasa Takahashi, Yuki Takahashi, Hirotaka Hamada, Augusto F Schmidt, Takushi Hanita, Shimpei Watanabe, Shinichi Sato, Hideyuki Ikeda, Erin L Fee, Lucy Furfaro, John P Newnham, Alan H Jobe, Nobuo Yaegashi, Masatoshi Saito.
A Reduction in Antenatal Steroid Dose Was Associated with Reduced Cardiac Dysfunction in a Sheep Model of Pregnancy.
Reproductive sciences (Thousand Oaks, Calif.), Jun 1, 2023  

Tsukasa Takahashi, Erin L Fee, Yuki Takahashi, Haruo Usuda, Sean W D Carter, Hideyuki Ikeda, Masatoshi Saito, Yusaku Kumagai, James P Bridges, Alan H Jobe, Mahesh A Choolani, Matthew W Kemp.
LPCAT1 levels in the placenta, the maternal plasma and the fetal plasma do not predict fetal lung responses to glucocorticoids in a sheep model of pregnancy.
Placenta, 138 1-9, Apr 18, 2023

2022
H. Usuda, S. Watanabe, Hanita T, M. Saito, S. Sato, H. Ikeda, Y. Kumagai, M.C. Choolani, M.W. Kemp.
Artificial placenta technology: History, potential and perception
Placenta, Oct, 2022  

Tsukasa Takahashi, Yuki Takahashi, Erin L Fee, Haruo Usuda, Lucy Furfaro, John P Newnham, Alan H Jobe, Matthew W Kemp.
Single nucleotide polymorphisms in surfactant protein A1 are not associated with a lack of responsiveness to antenatal steroid therapy in a pregnant sheep model.
Physiological reports, 10(19) e15477, Oct, 2022

Takahashi T, Jobe AH, Fee EL, Newnham JP, Schmidt AF, Usuda H, Kemp MW.
The Complex Challenge of Antenatal Steroid Therapy Non-Responsiveness.
Am J Obstet Gynecol. 2022 Aug 3:S0002-9378(22)00586-5. doi: 10.1016/j.ajog.2022.07.030. Online ahead of print. PMID: 35932879

Usuda H, Fee EL, Carter S, Furfaro L, Takahashi T, Takahashi Y, Newnham JP, Milad MA, Saito M, Jobe AH, Kemp MW.
Low-dose antenatal betamethasone treatment achieves preterm lung maturation equivalent to that of the World Health Organization dexamethasone regimen but with reduced endocrine disruption in a sheep model of pregnancy.
Am J Obstet Gynecol. 2022 Jul 2:S0002-9378(22)00534-8. doi: 10.1016/j.ajog.2022.06.058. Online ahead of print. PMID: 35792176

Haruo USUDA, Sean CARTER, Tsukasa TAKAHASHI, John P. NEWNHAM, Erin L. FEE, Alan H. JOBE, Matthew W. KEMP
Perinatal Care for the Extremely Preterm Infant 
Seminars in Fetal and Neonatal Medicine, 101334-101334, Apr, 2022 DOI:10.1016/j.siny.2022.101334

Erin L Fee, Tsukasa Takahashi, Yuki Takahashi, Sean Carter, Lucy Furfaro, Michael W Clarke, Mark A Milad, Haruo Usuda, John P Newnham, Masatoshi Saito, Alan Hall Jobe, Matthew W Kemp
1% of the clinical dose used for antenatal steroid therapy is sufficient to induce lung maturation when administered directly to the preterm ovine fetus. 
American journal of physiology. Lung cellular and molecular physiology, Apr 19, 2022
DOI:10.1152/ajplung.00058.2022

Tsukasa Takahashi, Yuki Takahashi, Erin L Fee, Masatoshi Saito, Nobuo Yaegashi, Haruo Usuda, James P Bridges, Mark A Milad, Lucy Furfaro, Sean Carter, Augusto F Schmidt, John P Newnham, Alan Hall Jobe, Matthew W Kemp
Continuous but not pulsed low-dose fetal betamethasone exposures extend the durability of antenatal steroid therapy. 
American journal of physiology. Lung cellular and molecular physiology, Apr 5, 2022
DOI:10.1152/ajplung.00018.2022